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Insulin therapy and crossing time zones

For trips that cross time zones, it may be necessary to adjust the timing or doses of insulin injections.

Between European countries, there are only a few hours of time difference, which do not need to be particularly considered; insulin injections can be moved directly to the local time. For intercontinental trips, time zone differences are larger. A time difference of more than 3 hours should be taken into account in insulin dosing.

The necessary changes depend on the injection program and the insulin preparations used. For trips under a week, it is generally advisable to administer basal insulin at the home country's injection time. For example, basal insulin injected around 21–22 in Finland can be injected around 14–15 in New York (7-hour time difference). Mealtime insulin is not affected by the time difference—it is always injected before eating.

Planning the insulin injection schedule should be done well in advance of the trip together with the treating doctor or diabetes nurse. A written plan of the injection schedule can be made in advance, noting both the home country and destination country times, flight schedule and duration, and planning the insulin injection times with any changes.

In insulin pump therapy, it's usually sufficient to set the pump's clock to the destination country's time upon arrival and to revert it to the home country's time upon return.

When traveling across several time zones in an east-west direction, the body's circadian rhythm gets disrupted as the local time and the body's internal clock are out of sync. The secretion of many hormones follows a strict circadian rhythm and adjusts slowly to the new time. Generally, adaptation to time difference is easier when traveling westward than eastward.

Symptoms of jet lag include fatigue and insomnia occurring at "wrong" times, headaches, irritability, difficulty concentrating, and gastrointestinal issues. These symptoms can partially resemble the sensations of low blood sugar. Adaptation to the time difference usually occurs best when one immediately starts following the local time of the destination. Jet lag can be reduced before flying by delaying bedtime and waking time before a westward flight, and advancing both for an eastward flight.

  • Administer insulin doses in local time before the flight.

  • The day lengthens when traveling west.

  • Increase the basal insulin according to the time difference hours, because the number of hours requiring basal insulin increases with the lengthening of the day.

  • The addition of basal insulin is based on how many hours the time difference is and how much the usual dose of basal insulin is per hour.

  • Glargine and degludec insulin dosing can continue every 24 hours if the injection time in the destination country is at a reasonable hour.

  • Meals during the flight are covered with rapid-acting insulin according to carbohydrate amounts.

  • Upon arrival in the destination country, follow the normal injection plan in local time. Doses are adjusted as necessary based on blood sugar.

Example:

If the amount of basal insulin is 20 units per day, this corresponds to approximately 0.8 units per hour. If the time difference is 6 hours, an additional dose of basal insulin of about 6 x 0.8 units, or 4-5 units, is administered. Due to the overlapping effects of insulins, the additional insulin dose is rounded down.

  • Inject insulin doses in local time before the flight.

  • The day shortens when traveling east.

  • Reduce the basal insulin according to the time difference hours, because the effects of basal insulin doses will otherwise overlap due to the day shortening.

  • Basal insulin is reduced according to how many hours the day shortens.

  • During meals, inject as usual according to the amount of carbohydrates eaten.

  • Upon arrival in the destination country, follow the normal injection plan in the local time of the destination country. Doses are adjusted as needed based on self-monitoring.

Example:

If the amount of basal insulin is 20 units per day and the time difference is 6 hours, the dose of the basal insulin injection is reduced by 5 units.

Updated 7.11.2023