Membranoproliferative glomerulonephritis in Helsinki and Uusimaa hospital district from 2006 to 2017
Marja Kovala and Anne Räisänen-Sokolowski (HUSLAB, Pathology)
The diagnostic criteria and classification of membranoproliferative glomerulonephritis (MPGN) has been revised and renewed during the last decade. Many of the patients previously diagnosed with MPGN have not had adequate diagnostic evaluation according to the modern standards. To date, there is lack of knowledge on the disease etiology and prognosis of the Finnish MPGN patients. The aim of the project is to re-evaluate the histology, clinical course and diagnostic investigations as well as treatments in MPGN patients living in the HUS-area.
Development of molecular diagnostic tools for early detection of schizophrenia
Dan Lindholm and Antti Vaheri (University of Helsinki)
The aim is to develop new molecular diagnostic tools for an early detection of schizophrenia.
Etiology of recurrent miscarriage – an immunological problem of early pregnancy?
Aila Tiitinen (HUS)
The aim is to study possible immunological disturbances behind recurrent miscarriage in secretory phase endometrium of women with recurrent miscarriage and healthy controls.
Mutations in the immune response pathways linked to autoimmune diseases
Satu Mustjoki and Mikko Tyster (University of Helsinki)
The study is focused on the autoimmune driven pathogenesis of certain hematological disorders, including LGL leukemia, aplastic anemia and hypoplastic myelodysplastic syndromes (hMDS). Mainly the project revolves around somatic mutations in immune pathways, but includes also the characterization of autoantibodies in patient plasma.
Idiopathic Orbital Inflammation in Finnish Population
Marita Uusitalo, Olli Tynninen and Veli-Matti Kuronen (HUS)
The aim is to study idiopathic orbital inflammation in the Finnish population in order to better identify and explicitly treat the disease.
Inflammatory Bowel Disease Translational Genetics (IBD TransGen)
Samuli Ripatti (Institute for Molecular Medicine Finland FIMM and Broad Institute of MIT and Harvard)
The aim of the study is to build a large (10 000 individuals) Finnish Inflammatory bowel disease (IBD) resource and explore Finnish characteristics in IBD genetics in order to identify genetic risk factors and possible protecting mutations for IBD.
Liittyvätkö Chlamydiales-lahkon äskettäin kuvatut bakteerit keskenmenoihin?
Mirja Puolakkainen (University of Helsinki and HUSLAB)
The aim is to clarify the role of bacteria of the Chlamydiales order in miscarriages and stillbirth. Placental tissue samples will be used.
Inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC)
Martti Färkkilä (HUS), Johanna Arola (HUS), Rauf Samaletdin (HUS), Vidya Velagaudi (FIMM)
The aim of the study is to characterize metabolomics, epigenetic and microbial differences of inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC) before and after the diagnosis of PSC