COVID-19-STUDIES

Julkaistu 11.8.2020 0.00

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The effect of montelukast therapy on airway inflammation in infant asthma

Kristiina Malmström & Mika Mäkelä (HUS)

Children <2 year of age with troublesome breathing, wheeze and a suspect for asthma were studied for lung function and for clinical reasons few children were remitted for bronchoscopy and biopsy. Carinal biopsies (50 cases) were analyzed for inflammation and remodeling. The present study is continuum to the original study plan. According to RNA-sequencing, epithelial inflammatory cells are of importance and immunostaining of the biopsies is needed. Virus-binding receptors at epithelial cells are important in asthma exacerbations and immunostaining of receptors for some viruses will be done and due to the Covid-19 pandemia, we will begin from novel virus SARS-CoV-2. These new immunostainings will be done at the collaboration laboratory at Groningen, Holland.

 

COVID-19 - identification of factors influencing the course of infection using HUS patient data

Minja Pehrsson, Miika Koskinen, Olli Carpén & al (HUS, Helsinki Biobank)

The study identifies factors affecting COVID-19 in HUS SARS-CoV-2-tested patients. The study utilizes electronic health information stored in the HUS Data Pool (eg diagnoses, laboratory measurements, medicines administered in the hospital) as well as genomic information produced from Helsinki Bank's biobank samples and medication information obtained from Kela. In this way, we aim to form an overall picture of the expression and severity of symptoms in COVID-19 patients. The aim of the study is to identify the specific features that predispose COVID-19-infected individuals to a severe form of the disease.

 

Incidence, development and risk factors for COVID-19 disease; cohort follow-up study

Karin Blomgren, Anu Kantele-Häkkinen & al (HUS, University of Helsinki)

We will contact approximately four hundred individuals who provided a biobank sample in 2018-2019. The contacted persons are asked to provide new blood samples during the COVID-19 epidemic and to respond to symptom questionnaires included in the study. The aim of the study is to obtain new information about the antibodies in the virus and the relationship between hereditary factors and the severity of symptoms.

 

Understanding the hereditary background of coronavirus (COVID-19) infection as part of FinnGen biobank research (www.finngen.fi)

A biobank survey covering the whole of Finland, involving all Finnish biobanks

Extensive individual variation in the course of coronavirus infection has been observed. One explanation for this may be individual differences in human genetic factors. The role of genetic factors in coronavirus infection is now being studied as part of the FinnGen research project covering the whole of Finland. The biobank samples collected in the FinnGen research project generally provide information on the hereditary background of many different diseases. Now the role of genes in coronavirus infection can be studied in people who have been infected and whose DNA has been analyzed as part of the FinnGen project. With the help of information from genetic factors, it would be possible, for example, to choose the most appropriate form of treatment for the patient. The study is part of the international COVID-19 Host Genetics Initiative research collaboration, which collects information on the genetic factors of people with coronavirus infection around the world.